美国空军的新式武器：一架F-22喷气式战斗机的原型被盗，这可关系到美国的国家安全问题。CIA警探阿列克斯·斯科特（欧文·威尔逊 饰）奉命展开调查，而上级派来与他搭档的竟是前世界拳击冠军凯利·罗宾森（艾迪·墨菲 饰），此君自以为是，而且还嬉皮笑脸，真是成事不足败事有余。经过调查，阿列克斯和凯利认定，盗窃F-22就是臭名昭著的军火走私商阿诺德·贡达尔斯（马尔科姆·麦克道威尔 饰）所为。尽管这一对搭档从一开始就显现出种种搭配不和谐的迹象，不过他们还是开始携手追捕阿诺德，过程中自然有不少笑料……
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